The Holy Spirit is an active participant in creation all the way back to Gen 1:1, as He moved over the surface of the water, and He continues to sustain us. In terms of a Creation Model, human design has a Holy Spirit interface design feature that should be characterized. This paper examines the biological extent to which individuals acting in our Imago Dei missional calling are supported by the work of the Holy Spirit. The premise is that the Holy Spirit uses and revitalizes an individual’s capabilities through engagement with their spirit, soul, and body. Redemption is not only a spiritual act but can be traced to the redemptive response in our body. The term that is used for this concept is biological redemption. Man’s heavenly final state will be with the glorified body God intends for us. In the present, we have biological redemption as a byproduct of spiritual formation and supportive spiritual community involvement. In clinical studies, prayer and spiritual activity have been proven to impact health and disease recovery. The Holy Spirit is a constant resource to empower individuals in our missional work, including refreshing our bodies in the fallen world. Our bodies are a necessary part of our human ministry. To share the Great Commission, a believer must engage other individuals physically using one’s body. Thus, the body must be in good order to do this missional role. The paper shares theological and biological insights into how our bodies can accomplish refreshing and remembering a restorative state. Paul shows us how he could transcend his situation through fellowship, prayer, singing of hymns, and glorifying God. His spirit was elevated, and his body was refreshed. At times even miraculous interventions took place (Acts 16:22-30). Epigenetic research shows one of the biological pathways to switch how the body responds due to spiritual and communal activity and to remember a redemptive state. Exploring biological redemption is a rewarding theological and biological endeavor where we can give God glory for how the body responds to the Holy Spirit’s handiwork.
