Iodine deficiency disorders are common throughout the world, caused biochemically by iodine deficiency, although that is sometimes exacerbated by the presence of antagonistic factors (goitrogens). Environmental iodine deficiency is assumed, but remains not-proven. Soil iodine levels, as well as water iodine, are not always directly related to the prevalence of the disorders, raising questions about the constancy and meaning of environmental deficiency. The role of the Flood in removing iodine from the environment has been crucial, leaving the world hovering on the edge of deficiency. It is unlikely that the uniformitarian paradigm can explain iodine deficiency as well as the Biblical Flood can. Despite the inferred enormous difference in pre-Flood and post-Flood iodine levels, the pre-Flood world probably did not suffer any iodine excess.